|
Symbol Name ID |
Disc1
disrupted in schizophrenia 1 MGI:2447658 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | EEG abnormality |
Abnormal nonverbal communicative behavior |
Delayed speech and language development |
Delusion |
Schizophrenia |
Hallucinations |
Negativism |
Lack of spontaneous play |
Impaired ability to form peer relationships |
Autism |
Autism with high cognitive abilities |
Inflexible adherence to routines |
Motor stereotypy |
Restrictive behavior |
Social and occupational deterioration |
Intellectual disability |
Seizure |
| Disease(s) Associated with DISC1 | |||||||||||||||||
| Asperger syndrome | |||||||||||||||||
| autistic disorder | |||||||||||||||||
| schizophrenia |
| Mouse Phenotypes | nervous system phenotype |
abnormal axon extension |
abnormal neuron proliferation |
abnormal brain interneuron morphology |
decreased brain size |
enlarged lateral ventricles |
dilated lateral ventricle |
decreased corpus callosum size |
small thalamus |
abnormal entorhinal cortex morphology |
thin cerebral cortex |
small cerebellum |
abnormal neuron morphology |
abnormal neurite morphology |
abnormal dendrite morphology |
decreased neuron number |
abnormal CNS synaptic transmission |
abnormal long-term potentiation |
reduced long-term potentiation |
abnormal prepulse inhibition |
decreased prepulse inhibition |
increased prepulse inhibition |
abnormal synaptic depression |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||
| Disc1em1(IMPC)Mbp/Disc1em1(IMPC)Mbp | ||||||||||||||||||||||||
| Disc1Rgsc1390/Disc1Rgsc1390 | ||||||||||||||||||||||||
| Disc1Rgsc1393/Disc1Rgsc1393 | ||||||||||||||||||||||||
| Disc1tm1Kozo/Disc1tm1Kozo | * | |||||||||||||||||||||||
| Disc1Rgsc1390/Disc1+ | ||||||||||||||||||||||||
| Disc1Rgsc1390/Disc1Rgsc1393 | ||||||||||||||||||||||||
| Disc1Rgsc1393/Disc1+ | * | |||||||||||||||||||||||
| Tg(Camk2a-ESR1/Disc1*)2698.1Sva/0 | ||||||||||||||||||||||||
| Tg(Disc1/EGFP)M19Sshe/0 | ||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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